It's no different. Regardless of ignition setup, the ecu knows exactly when each cylinder is going to be fired. Ive already identified the ins and outs.

With wasted spark, the adjusted timing will fire on both the compression and exhaust cylinders, so it's no big deal.

And with a dizzy, same odds really. The ecu still knows which cylinder. That's the only key though.

The ecu must be listening for knock based on crank position. It cant be a basic system where it just blindly listens for knock at any time. But those systems are also very prone to random noise it may think is knock. Hence closing down the window where it listens makes it sooo much better.