We went last year for 4 days. Flew in as part of our America trip and met my parents who flew over from the UK. We stayed at Ceasars Palace and the Venetian (extended our stay by 1 day and Ceasars wouldnt give the same rate).
There is a huge designer outlet about a 20 min taxi ride away and back then when the US and AUD $$ were near parity, i got a lot of items very cheaply. Don't bus it there, my parents did and in 40 degrees, wasnt pretty.
We drove to Kingman which I believe is the closest point for Route 66, went to a diner and had lunch. You cross the Hoover Dam to get there which was awesome. Grand Canyon is a fair drive to the closest point but the arch platform is an overnighter from Vegas or a very very long day and not much time at the platform.
Really nice place and amazing to see the pace of development. I have stacks of photos on the media center but the above ones give a good idea.