All about the person and the state of mind. The people I know who have, have been outwardly happy people.
But, i dare say that deep down they have a low selfasteem, and must view it as easier for it to just be over, than struggle on.
One chap I know, decent looking bloke, lots of friends, family was good, then hung himself after his misses started shagging round. Supose at that point none of the above mattered in comparison to the feeling of being cheated on and couldn't go on.
Personally I couldn't do it.