With the horse power you will be running you maybe want to look at a swirl tank or a sump being fabricated to the bottom of your tank. I would have a sump welded in to the tank with your -10 fitting for the prefilter then -10 to pump then -6 to -6 second filter (could be mounted in engine bay ) then -6 all the way to your fuel rail , then -6 from your fuel rail to your fuel pressure regulator then -6 from the return port on the regulator all the way back to the tank . If you have a sump made for the tank then put the fuel return pipe at the top of the sump so it's always filling the lowest section of your fuel tank so you can run nearly all your fuel with running dry. Also you can weld a -6 fitting on the bottom or low down on the side for a fuel drain fitted with a blanking plug.
Hope this helps

Cheers paul