I,ve got 6 Deg and supra diff fitted and yes it will need modding.

My centre box is quite long and is rattling on a trailing arm adjuster, so I,m going to get the centre box moved forward 3" so it's in front of the beam and arms.

Also where it comes under the front mounting point of the diff, I had an inch sized area hammered in (down) 10mm, to stop the top of the exhaust pipe rattling on the countersunk Allen key bolt head.