No while your actually spraying no!! but most of the things above are right but as dingla said make sure you get a decent mask cos isocynates arnt nice lol.

Also depends if you use water based or solvent, if its a striaght colour try and get some high solids in the same colour, it will cover any inperfections alot better and easier to flat shit/runs out after whereas if your prep isnt too good it'll show up with basecoat once you have the lacquer on!!

Then the obvious, panel wipe, and tack rags to clean any dust off prior to spraying!!

Also if you use waterbased in a cold enviroment it takes forever and a day to flash off but if you just pull the trigger so you get air and no paint and woft it over the panel it'll flash off quicker.

Also what gun are you going to use?! oh and if you can an inline filter can help as any moisture/water in the compressor tank will go into the paint and can cause problems too!!!