Steve
I run 225/45R16 with ET30 on the racecar and have had to trim flange off the bodykit, roll the arch flange, trim some of the arch nearest the rear wheel and also trim back some of the bumper flange. You can gain more clearance running eccentric top mounts and if you don't then you need to be careful if you use adjustable lower arms because you can widen the track to gain camber and start to rub. As mentioned the castor setting can influence too. Best thing you can do is mount your damper without the spring and articulate the wheel to check where you will have issues. Cheers