yes look for a program called a "glide wrapper"

i take it this "game" is an N64 emulator? lol

as for 2x GFX cards, you can run em as seperate screens, either get a card that supports twin monitors, or use 2 cards :P windows will recognise both cards and you can set it very easily to display different bits on each other :P if you do i HIGHLY reccomend a program called "ultramon" which does a brilliant job of seperating the desktops on each screen