That sort of power is childs play, the main difference between 2wd and 4wd heads is in the cooling passages, and the passageways from head to block in the head.
The 2wd has long slots, the 4wd has holes, that better support the gasket, the cooling system was also redesigned on the 4wd, the pump itself has masses more flow capacity for a start.
After that though, the 2wd will be totally unfussed about that power level, they were intended to have around 300bhp to start with, it was ford that insisted on a detune, so as not to upset the M3 boys too much!!
There can be a big variation of flow on injectors, I would go larger than dark greens(803's), I would use greys, combine this with a decent mapping session and it will be fine, I run greys(403's) at 300bhp and can get 40mpg on a run, but average around 27mpg short runs stuff, idle co is 0.97% perfection.
If you are going to do any future mods(you will!!) then carefully consider a aftermarket ecu, there are loads to choose from, some buy just because it has a "known" name, don't waste your money when you can get a lot cheaper that will do what you want just as well.
Also consider who is going to map it, where they are don't want 1000mile round trip for mapping, well actually that would be a good excuse for a blast, so you might want that!!
For the power you want a T34.48 will be perfect and punchy low down, keep std cams/head/CR.
tabetha