Trapped in a plane for 7 hours with someone else's kid screaming and puking everywhere. HEAVEN!!
Only joking, we have two (grown up now) and, although they were usually well behaved on planes, they had their moments.
A mate of mine took his kids on a plane travelling business class from Rome and their wee lad threw a major tantrum that lasted for hours. It got so loud and so bad, and lasted for so long that my mate and his wife were ready to throw themselves out the window. Some of their fellow passengers were NOT at all sympathetic - mind you, if I had paid as much for my luxury seat in peaceful surroundings I may well have been the same!