I've got a 2wd and a 4X4 Saph at the moment and they are like chalk and cheese to drive.
The 4X4 is running about 280bhp and the 2wd is around the 330bhp mark.
I love the confidence that the 4X4 gives you and I've never had any issues with transmission problems.
The 2wd on the other hand is a beast and a bit of a handful. Treat it with respect and you'll be fine.
