Goto the Zap, Audio, Honey Club or the Ocean Rooms.

Avoid: Creation or anywhere down West St as its towny shite.

My personal favourite is the Zap - hard house, tech house and a discerning clientele ensures no beer boys.

Enjoy!

PS: And yes there is a large gay community, but you'll not get bothered by them - in fact they know how to have a better night out than most of my straight friends.