Dont ever reply to spam!
All it does is prove they have found a live email account.
I had to give up on my email address and start a new one cos i was getting 40 or 50 a day.
Every month or so - i would just delete everything, but I had an automated reply that said something like "fuck you spammer, if i havent given you my new address it means i dont want to hear from you!"
It got worse and worse, till i removed the auto reply.
Now its more like 3 or 4 a day.