To be honest with you if your still getting pop ups even after trying various different things then your PC is probably too badly infected with spyware to cure, short of a full restore.

My laptop got to the stage where i had a never ending "Come meet me at pussy palace" pop up, if u closed it another one would pop up, the only way was to drag it out of the way, plus a continual "ding ding ding ding ding" playing through the speakers.

Ive restored it now and with the service packs kept up to date i have NO pop ups and i dont have any additional blockers or spyware software.

AVG free edition anti virus and thats should be all you should need really.