You need a way to combat det, ie run rocket fuel, on pump fuel its a nono.

Next problem is huuuuge in-cyl pressures, so you need a properly mega strong engine (inc block generally).

Long duration cams and huge exhaust housings will help too, but frankly, i dont see the point in most cases.
The long duration cams and huge ex housings will push the boost threshold mega high, so although it will drive like a standard n/a cammed engine until it comes on boost (wowee, 100bhp on a good day from a 2litre sub 4500rpm), it wont come on boost till higher up.

Personally id rather run lower comp with smaller ex housings and lower duration cams, so it wont have quite as much power off boost, but who gives a fuck if it comes on boost sooner.

Hi comp has its uses, but for road cars running big bhp per litre on pump fuel, its pointless/useless IMO.